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OB-24 (free base)

CAT: 0804-HY-118487ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118487ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol[1].
CAS Number
940061-39-2
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ob-24-free-base.html
Smiles
BrC1=CC=C(CCC2(CN3C=NC=C3)OCCO2)C=C1
Molecular Formula
C15H17BrN2O2
Molecular Weight
337.21
References & Citations
[1]Alaoui-Jamali MA, et al. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009;69 (20) :8017-8024.|[2]A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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