OB-24

• Description :

  OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM) . OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis[1][2].

• Product Name Alternative :

  BHI1

• UNSPSC :

  12352005

• Target :

  Heme Oxygenase (HO) ; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ob-24.html

• Purity :

  98.21

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  BrC1=CC=C(CCC2(CN3C=CN=C3)OCCO2)C=C1.Cl

• Molecular Formula :

  C15H18BrClN2O2

• Molecular Weight :

  373.67

• References & Citations :

  [1]Alaoui-Jamali MA, et al. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009;69 (20) :8017-8024.|[2]Moulay. Alaoui-Jamali, et al., OB-24, a novel selective and potent HO-1 inhibitor, induces a wide spectrum anti-tumor activity in vitro and in vivo and synergizes with chemotherapy drugs. Mol Cancer Ther 1 November 2007; 6 (11_Supplement) : C82.|[3]Roman, G., et al., (2007) . Heme oxygenase inhibition by 2-oxy-substituted 1- (1H-imidazol-1-yl) -4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorganic & medicinal chemistry, 15 (9), 3225–3234.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HO-1; HO-2

• CAS Number :

  [939825-12-4]