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OB-24

CAT: 0804-HY-118487-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-118487-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM) . OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis[1][2].
CAS Number
[939825-12-4]
Product Name Alternative
BHI1
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ob-24.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
BrC1=CC=C(CCC2(CN3C=CN=C3)OCCO2)C=C1.Cl
Molecular Formula
C15H18BrClN2O2
Molecular Weight
373.67
References & Citations
[1]Alaoui-Jamali MA, et al. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009;69 (20) :8017-8024.|[2]Moulay. Alaoui-Jamali, et al., OB-24, a novel selective and potent HO-1 inhibitor, induces a wide spectrum anti-tumor activity in vitro and in vivo and synergizes with chemotherapy drugs. Mol Cancer Ther 1 November 2007; 6 (11_Supplement) : C82.|[3]Roman, G., et al., (2007) . Heme oxygenase inhibition by 2-oxy-substituted 1- (1H-imidazol-1-yl) -4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorganic & medicinal chemistry, 15 (9), 3225–3234.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HO-1; HO-2

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