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FGFR4-IN-20

CAT: 0804-HY-163569Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163569Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor with IC50s of 19 and 36 nM against Huh7 cells and FGFR4 enzyme. FGFR4-IN-20 can be used for hepatocellular carcinoma research[1].
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-20.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C2=CC3=CN=C(C=C3C(C)=N2)NC4=C(C=CC=C4)NC(C=C)=O)C(Cl)=C(OC)C=C1OC
Molecular Formula
C26H22Cl2N4O3
Molecular Weight
509.38
References & Citations
[1]Oh H, et al. Discovery of 2,6-Naphthyridine Analogues as Selective FGFR4 Inhibitors for Hepatocellular Carcinoma. J Med Chem. 2024 May 23;67 (10) :8445-8459.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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