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FGFR4-IN-10

CAT: 0804-HY-146541Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146541Size:1 Each
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Description
FGFR4-IN-10 (compound 5a) is a potent and selective FGFR4 inhibitor with an IC50 value of 70.7 nM. FGFR4-IN-10 shows no inhibition against other FGFR family members, i.e. FGFR1, FGFR2 and FGFR3[1].
CAS Number
2857862-25-8
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-10.html
Solubility
10 mM in DMSO
Smiles
COCCNC1=C(C=NC(NC(N2CCCC3=CC=C(N=C32)C(C(F)(F)F)=O)=O)=C1)C#N
Molecular Formula
C20H19F3N6O3
Molecular Weight
448.40
References & Citations
[1]Zhen Zhang, et al. Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg Med Chem. 2021 Nov 15;50:116457.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T62682-01FGFR4-IN-10
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