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FGFR4-IN-11

CAT: 0804-HY-147515Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147515Size:1 Each
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Description
FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].
CAS Number
2396664-85-8
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-11.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C(C2=CNC3=NC(NC4=C(C=C(C=C4)N5CCOCC5)NC(C=C)=O)=CC=C32)=O)=CC(OC)=C1
Molecular Formula
C29H29N5O5
Molecular Weight
527.57
References & Citations
[1]Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65 (10) :7278-7295.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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GTR19184923-01FGFR4-IN-11
562673-01FGFR4
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