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FGFR4-IN-14

CAT: 0804-HY-155046Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155046Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC50: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC50s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC) [1].
CAS Number
3027827-02-4
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-14.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=CC2=C(C=C1C3=NNC4=C3C=C(O[C@@H](C5=C(Cl)C=NC=C5Cl)C)C=C4)CCN(C)C2)=O
Molecular Formula
C27H25Cl2N5O2
Molecular Weight
522.43
References & Citations
[1]Yang Y, et al. Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants. Eur J Med Chem. 2023 Oct 5;258:115628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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