PROTAC-O4I2

• Description :

  PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1) . PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; PROTACs; SF3B1

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/protac-o4i2.html

• Concentration :

  10mM

• Purity :

  99.56

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCCCCCNC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O)C4=CSC(NC5=CC=C(C=C5)Cl)=N4

• Molecular Formula :

  C29H29ClN6O5S

• Molecular Weight :

  609.10

• References & Citations :

  [1]Rodrigo A Gama-Brambila, et al. A PROTAC targets splicing factor 3B1. Cell Chem Biol. 2021 Nov 18;28 (11) :1616-1627.e8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [2785323-62-6]