PROTAC-O4I2

• Description:

  PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1) . PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; PROTACs; SF3B1

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-o4i2.html

• Concentration:

  10mM

• Purity:

  99.56

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C (NCCCCCCNC1=CC=CC2=C1C (N (C2=O) C3CCC (NC3=O) =O) =O) C4=CSC (NC5=CC=C (C=C5) Cl) =N4

• Molecular Formula:

  C29H29ClN6O5S

• Molecular Weight:

  609.10

• References & Citations:

  [1]Rodrigo A Gama-Brambila, et al. A PROTAC targets splicing factor 3B1. Cell Chem Biol. 2021 Nov 18;28 (11) :1616-1627.e8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  2785323-62-6