PROTAC CG167

• Description :

  PROTAC CG167 is a selective and potent CypA PROTAC degrader. PROTAC CG167 degrades CypA in a dose-dependent manner (Jurkat: DC50: 123 nM) . PROTAC CG167 can inhibit HIV-1 and HCV and exhibits antiviral activity[1]. (Pink: CypA Ligand (HY-170997) ; Black: Linker (HY-W123015) ; Blue: E3 Ligase Ligand (HY-112078) )

• UNSPSC :

  12352005

• Target :

  Cyclophilin; HCV; HIV; PROTACs

• Related Pathways :

  Anti-infection; Immunology/Inflammation; PROTAC

• Field of Research :

  Infection

• Smiles :

  CC1=C(C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@@H](NC(CCCCCN4N=NC(CCC[C@@H](OC([C@H]5NN(CCC5)C([C@H](C)NC([C@@H](NC(C/C=C/6)=O)CC7=CC=C(C=C7)[N+]([O-])=O)=O)=O)=O)C8=CC=C9C=CC6=CC9=N8)=C4)=O)C(C)(C)C)=O)O)=O)C)SC=N1

• Molecular Formula :

  C65H79N13O11S

• Molecular Weight :

  1250.47

• References & Citations :

  [1]Newton LS, et al. Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cyclophilin A; HIV-1