TAT-PiET-PROTAC

• UNSPSC Description:

  TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445). TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can disrupt the interaction between the breast cancer oncogene BRD4/JMJD6 and inhibit the growth of breast cancer cells. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells and is a potential inhibitor of breast cancer[1].

• Target Antigen:

  Epigenetic Reader Domain; Radionuclide-Drug Conjugates (RDCs)

• Type:

  Peptides

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/tat-piet-protac.html

• Smiles:

  O=C([C@@H](N)CC1=CC=C(O)C=C1)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CCC(NCCCCCC(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@H](CC)C)=O)CC3=CC=C(O)C=C3)=O)CC(O)C2)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)CS)=O)CCCCN)=O)CC5=CC=CC=C5)=O)CCCCN)=O)CCC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O

• Molecular Weight:

  3316.85

• References & Citations:

  [1]Huang QX, et al. Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo. J Med Chem. 2024 Apr 25;67(8):6658-6672.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported