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Thalidomide-O-COOH

CAT: 0804-HY-103597-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103597-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].
CAS Number
1061605-21-7
Product Name Alternative
Cereblon ligand 3; E3 ligase Ligand 3
UNSPSC
12352005
Hazard Statement
H301, H312, H360
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3_ligase_Ligand_3.html
Purity
99.85
Solubility
DMSO : ≥ 42 mg/mL
Smiles
O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(O)=O
Molecular Formula
C15H12N2O7
Molecular Weight
332.27
Precautions
H301, H312, H360
References & Citations
[1]Bozilovic J, et al. Novel, highly potent PROTACs targeting AURORA-A kinase. Current Research in Chemical Biology. 2022, 2: 100032.|[2]Yamanaka S, et al. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nat Commun. 2023 Aug 18;14 (1) :4683.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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