NMDAR antagonist 2

• UNSPSC Description:

  NMDAR antagonist 2 (compound 3I) is a CNS penetrant NMDAR antagonist with the IC50 of 4.42 μM and 214.75 μM for hGluN1/hGluN2A at −60 mV or 40 mV membrane potentials, respectively. NMDAR antagonist 2 can reduce hippocampal damage[1].

• Target Antigen:

  iGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nmdar-antagonist-2.html

• Smiles:

  OCCNC1C2=CC=CC=C2CCC3=CC=CC=C13.Cl

• Molecular Weight:

  289.80

• References & Citations:

  [1]Konecny J, et al. Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects. Eur J Med Chem. 2024;280:116981.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported