NMDAR/HDAC-IN-1

NMDAR/HDAC-IN-1

• UNSPSC Description: NMDAR/HDAC-IN-1 (Compound 9d) is a dual NMDAR and HDAC inhibitor with a Ki of 0.59 μM for NMDAR and IC50 values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier[1].
• Target Antigen: HDAC; iGluR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nmdar-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC12CC3CC(C1)(CC(C3)(C2)NC(/C=C/C4=CC=C(C=C4)C(NO)=O)=O)C
• Molecular Weight: 368.47
• References & Citations: [1]He F, et al. Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104109.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported