NMDAR/HDAC-IN-1

• UNSPSC Description:

  NMDAR/HDAC-IN-1 (Compound 9d) is a dual NMDAR and HDAC inhibitor with a Ki of 0.59 μM for NMDAR and IC50 values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier[1].

• Target Antigen:

  HDAC; iGluR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nmdar-hdac-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC12CC3CC(C1)(CC(C3)(C2)NC(/C=C/C4=CC=C(C=C4)C(NO)=O)=O)C

• Molecular Weight:

  368.47

• References & Citations:

  [1]He F, et al. Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104109.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported