GluN2B-NMDAR antagonist-2

GluN2B-NMDAR antagonist-2

• UNSPSC Description: GluN2B-NMDAR antagonist-2 (compound S-58) is a potent, selective and cross the blood-brain barrier NMDAR-GluN2B antagonist with an IC50 value of 74.01, nM. GluN2B-NMDAR antagonist-2 shows mild cytotoxicity. GluN2B-NMDAR antagonist-2 decreases the cerebral infarction rates and neurologic deficit scores. GluN2B-NMDAR antagonist-2 has the potential for the research of stroke[1].
• Target Antigen: iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/glun2b-nmdar-antagonist-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=CC=C12)O[C@H]2CCCN(CC3)CCN3C(C4=CC(C=CC=C5Cl)=C5N4)=O.Cl
• Molecular Weight: 474.38
• References & Citations: [1]Lin G, et al. Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain-Penetrant and In Vivo Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment. J Med Chem. 2024 Feb 27.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported