Monomethyl auristatin E intermediate-15
CAT:
804-HY-79196-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Monomethyl auristatin E intermediate-15
- CAS Number: 173653-47-9
- UNSPSC Description: Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Applications: Cancer-programmed cell death
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-15.html
- Purity: 96.63
- Solubility: 10 mM in DMSO
- Smiles: O[C@H]([C@H](C)C(OCC1=CC=CC=C1)=O)[C@H]2N(C(OC(C)(C)C)=O)CCC2
- Molecular Weight: 363.454
- References & Citations: [1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported