Monomethyl auristatin E intermediate-1

• UNSPSC Description:

  Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-1.html

• Purity:

  99.93

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC[C@H](C)[C@H](NC)[C@H](OC)CC(OC(C)(C)C)=O.Cl

• Molecular Weight:

  295.85

• References & Citations:

  [1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  120205-48-3