SDH-IN-12

• Description:

  SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC50s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants[1].

• UNSPSC:

  12352005

• Target:

  Fungal; Succinate Dehydrogenase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sdh-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=C(C2=CC(F)=C(F)C(F)=C2)C=CC=C1)NC(C3=CN(C)N=C3C(F)F)=O

• Molecular Formula:

  C19H13F5N4O2

• Molecular Weight:

  424.32

• References & Citations:

  [1]Sun NB, et al., Novel Pyrazole Acyl (thio) urea Derivatives Containing a Biphenyl Scaffold as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Fungicidal Activity, and SAR. J Agric Food Chem. 2024 Feb 7;72 (5) :2512-2525.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [3027210-28-9]