Epothilone D
CAT:
804-HY-15278-04
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Epothilone D
- CAS Number: 189453-10-9
- UNSPSC Description: Epothilone D (KOS 862) is a potent microtubule stabilizer.
- Target Antigen: Antibiotic; Bacterial; Fungal; Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Infection
- Assay Protocol: https://www.medchemexpress.com/Epothilone-D.html
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: O=C(O[C@@H](C/C=C(CCC[C@@H]([C@@H]([C@H](C1=O)C)O)C)/C)/C(C)=C/C2=CSC(C)=N2)C[C@@H](C1(C)C)O
- Molecular Weight: 491.68
- References & Citations: [1]Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.
 Invest New Drugs. 2012 Dec;30(6):2294-302.|[2]Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
 J Neurosci. 2010 Oct 13;30(41):13861-6.
- Shipping Conditions: Blue Ice
- Clinical Information: Phase 2