Epothilone D

• UNSPSC Description:

  Epothilone D (KOS 862) is a potent microtubule stabilizer.

• Target Antigen:

  Antibiotic; Bacterial; Fungal; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/Epothilone-D.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(O[C@@H](C/C=C(CCC[C@@H]([C@@H]([C@H](C1=O)C)O)C)/C)/C(C)=C/C2=CSC(C)=N2)C[C@@H](C1(C)C)O

• Molecular Weight:

  491.68

• References & Citations:

  [1]Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. Invest New Drugs. 2012 Dec;30(6):2294-302.|[2]Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci. 2010 Oct 13;30(41):13861-6.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  Phase 2

• CAS Number:

  189453-10-9