Epothilone A
CAT:
804-HY-13503-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Epothilone A
- CAS Number: 152044-53-6
- UNSPSC Description: Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.
- Target Antigen: Apoptosis; Microtubule/Tubulin
- Type: Natural Products
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Epothilone_A.html
- Smiles: O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O
- Molecular Weight: 493.66
- References & Citations: [1]Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41.|[2]Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811.
- Shipping Conditions: Blue Ice