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N.41

CAT: 0804-HY-124870Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124870Size:1 Each
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Description
N.41 is an antiviral agent. N.41 protects APOBEC3G (an antiviral factor) from HIV Vif protein-mediated degradation. N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner. N.41 inhibits HIV-1 viral replication in PBMCs (IC50: 8.4 μM) [1].
CAS Number
357441-99-7
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/n-41.html
Smiles
C/C(NC1=CC=C(O)C=C1)=C\C(C2=CC=CN=C2)=O
Molecular Formula
C15H14N2O2
Molecular Weight
254.28
References & Citations
[1]Pery E, et al. Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem. 2015 Apr 17;290 (16) :10504-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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