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TIGIT Detection Set

CAT: 0223-SD8800Size: 1 SetDry Ice: YesHazardous: No
CAT#:0223-SD8800Size:1 Set
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH) . TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1) . Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2) .
Host
Llama
Reactivity
Human
Immunogen
TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Detection Sets
Purification
TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
Concentration
Antibody 1 mg/mL
Buffer
TIGIT Antibodies are supplied in PBS.
Shipping Conditions
Dry Ice
Storage Conditions
TIGIT antibodies should be stored in working aliquots at -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
Sdab
Background Reference 01
Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009; 106:17858-63.
Background Reference 02
Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8 (+) T cell effector function. Cancer Cell 2014; 26:923-37.
Tested Applications
ELISA, IHC-P, ICC, IF, Flow
Physical Properties
Liquid

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