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GITR Ligand Recombinant Protein

CAT: 0223-96-999Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-999Size:0.1 mg
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Background
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS) . TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
CAS Number
9000-83-3
NCBI Gene ID
294099
Swiss Prot
Q7TS55 (T157N)
Accession Number
AAO89011
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
41.4 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
GITR ligand
NCBI Organism
Mus musculus
Background Reference 01
Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
Background Reference 02
Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.
Other Product Names
TNFSF18, AITRL, TL6, hGITRL, GITR Ligand
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized

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