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TNF-alpha Recombinant Protein

CAT: 0223-96-958Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-958Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
CAS Number
9000-83-3
NCBI Gene ID
7124
Accession Number
NP_000585.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Chemokines & Cytokines, Growth Factors
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
18.2 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Tumor necrosis factor
NCBI Organism
Homo sapiens
Background Reference 01
Dowlati Y, Herrmann N, et al., 2010, Biol Psychiatry 67 (5) : 446–457.
Background Reference 02
Swardfager W, Lanctot K, et al., 2010, Biol Psychiatry 68 (10) : 930–941.
Background Reference 03
Locksley RM, Killeen N et al., 2001, Cell 104 (4) : 487–501.
Other Product Names
DIF, TNF-alpha, TNFA, TNFSF2, cachexin, cachectin, TNFalpha
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

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