TNF-alpha Recombinant Protein

• Background:

  Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

• NCBI Gene ID:

  7124

• Accession Number:

  NP_000585.2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Chemokines & Cytokines, Growth Factors

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  18.2 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  Tumor necrosis factor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dowlati Y, Herrmann N, et al., 2010, Biol Psychiatry 67 (5) : 446–457.

• Background Reference 02:

  Swardfager W, Lanctot K, et al., 2010, Biol Psychiatry 68 (10) : 930–941.

• Background Reference 03:

  Locksley RM, Killeen N et al., 2001, Cell 104 (4) : 487–501.

• Other Product Names:

  DIF, TNF-alpha, TNFA, TNFSF2, cachexin, cachectin, TNFalpha

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3