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TNF-alpha multimeric Recombinant Protein

CAT: 0223-90-231Size: 10 µgDry Ice: NoHazardous: No
CAT#:0223-90-231Size:10 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (human) (multimeric) (rec.) (Prod. No. AG-40B-0019) . Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha™ can be used.
CAS Number
9000-83-3
NCBI Gene ID
7124
Swiss Prot
P01584
Accession Number
P01375
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Obesity, Signal Transduction
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Tumor necrosis factor
NCBI Organism
Homo sapiens
Other Product Names
ACRP30headless:TNF-alpha, ACRP30headless:TNFSF2, ACRP30headless:Tumor Necrosis Factor-alpha
Species
Human, Mouse
Protein ID
135934
Physical Properties
Lyophilized

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