CD40L multimeric Recombinant Protein

CAT: 0223-90-225Size: 10 µgDry Ice: NoHazardous: No
CAT#:0223-90-225Size:10 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
CAS Number
9000-83-3
NCBI Gene ID
959
Swiss Prot
O75509
Accession Number
P29965
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Apoptosis, Immunology, Signal Transduction
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
CD40 ligand
NCBI Organism
Homo sapiens
Other Product Names
ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L
Species
Human
Protein ID
231718
Physical Properties
Lyophilized

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