CD40L multimeric Recombinant Protein

CAT: 0223-90-289Size: 10 µgDry Ice: NoHazardous: No
CAT#:0223-90-289Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
CAS Number
9000-83-3
NCBI Gene ID
84349
Swiss Prot
Q8WWZ1
Accession Number
Q9Z2V2
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
CHO cells
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Cd40lg
NCBI Organism
Rattus norvegicus
Other Product Names
ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L
Species
Human, Mouse, Rat
Protein ID
21362974
Physical Properties
Lyophilized

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