APRIL multimeric Recombinant Protein

• Background:

  APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

• NCBI Gene ID:

  69583

• Swiss Prot:

  Q8R459

• Accession Number:

  Q9D777

• Tag:

  DDDDK Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Concentration:

  0.1mg/ml after reconstitution.

• Buffer:

  Contains PBS + 0.5% Trehalose. Reconstitute with 100 μ l sterile water.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 13

• NCBI Organism:

  Mus musculus

• Other Product Names:

  ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:

• Species:

  Human, Mouse

• Protein ID:

  21363035

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3