CD40L multimeric Recombinant Protein

• Background:

  MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.

• NCBI Gene ID:

  21947

• Swiss Prot:

  P14778

• Accession Number:

  P27548

• Tag:

  DDDDK Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Immunology

• Concentration:

  0.1mg/ml after reconstitution.

• Buffer:

  Contains PBS. Reconstitute with 100 μ l sterile water.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  CD40 ligand

• NCBI Organism:

  Mus musculus

• Other Product Names:

  ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L

• Species:

  Human, Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3