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VLDLR Recombinant Protein

CAT: 0223-96-778Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-778Size:0.1 mg
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Background
The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene. A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.
CAS Number
9000-83-3
NCBI Gene ID
7436
Swiss Prot
P98155
Accession Number
AAI42654
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Neuroscience, Obesity, Signal Transduction
Purity
>97% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
83 kDa, The protein migrates as 110-120 kDa under reducing (R) condition (SDS-Page) due to different glycosylation.
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Very low density lipoprotein receptor
NCBI Organism
Homo sapiens
Background Reference 01
Sakai J, Hoshino A, Takahashi S, et al., 269 (3) : 2173–82.
Background Reference 02
Moheb LA, Tzschach A, Garshasbi M, et al. Eur. J. Hum. Genet. 16 (2) : 270–3.
Background Reference 03
Boycott KM, Flavelle S, Bureau A, et al., 2005, Am. J. Hum. Genet. 77 (3) : 477–83.
Other Product Names
VLDLR, RP11-320E16.1, CHRMQ1, FLJ35024, VLDLRCH, VLDL receptor
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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