Tim-3 Recombinant Protein

CAT: 0223-90-549Size: 100 µgDry Ice: NoHazardous: No
CAT#:0223-90-549Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.
CAS Number
9000-83-3
NCBI Gene ID
84868
Swiss Prot
O77457
Accession Number
NP_116171
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Cancer, Cell Cycle, Immunology
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μ l sterile water. Add 1X PBS to the desired protein concentration.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Hepatitis A virus cellular receptor 2
NCBI Organism
Homo sapiens
Other Product Names
TIM3, TIMD3, Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T Cell Immunoglobulin and Mucin Domain-containing Protein 3
Species
Human
Protein ID
49574534
Physical Properties
Lyophilized

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