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PPM1A Recombinant Protein

CAT: 0223-91-141Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-141Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
CAS Number
9000-83-3
NCBI Gene ID
5494
Swiss Prot
P35813
Accession Number
P35813
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
43.5 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Protein phosphatase, Mg2+/Mn2+ dependent 1A
NCBI Organism
Homo sapiens
Other Product Names
Protein Phosphatase 1A, Protein Phosphatase 2C Isoform Alpha, PP2C-Alpha, Protein Phosphatase IA, PPM1A, PPPM1A, PP2C alpha
Species
Human
Physical Properties
Liquid

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