PPM1A Antibody

• Background:

  The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

• NCBI Gene ID:

  5494

• Swiss Prot:

  P35813

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PPM1A (NP_066283.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  MCF-7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 42kDa

• Fragment:

  IgG

• Symbol:

  PPM1A

• Positive Control 2:

  HeLa

• Positive Control 3:

  HepG2

• Positive Control 4:

  SH-SY5Y

• Positive Control 5:

  Mouse liver

• Positive Control 6:

  Mouse skeletal muscle

• NCBI Official Name:

  Protein phosphatase, Mg2+/Mn2+ dependent, 1A

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PPM1A, PP2Calpha, Protein phosphatase 1A, Protein phosphatase 2C alpha, Protein phosphatase IA, PP2CA, PPPM1A, PP2C-ALPHA

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid