Progranulin Recombinant Protein

• Background:

  Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD) . In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment) . Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

• NCBI Gene ID:

  29143

• Swiss Prot:

  Q8WWZ1

• Accession Number:

  NP_058809

• Tag:

  DDDDK Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Granulin

• NCBI Organism:

  Rattus norvegicus

• Other Product Names:

  Proepithelin, PEPI, PC Cell-derived Growth Factor

• Species:

  Rat

• Protein ID:

  224967120

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3