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Progranulin Antibody

CAT: 0223-36-314Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-36-314Size:100 µg
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Background
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD) . In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment) . Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
NCBI Gene ID
2896
Swiss Prot
P28799
Accession Number
4504151
Host
Guinea pig
Reactivity
Human
Immunogen
Recombinant human progranulin.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Innate Immunity, Obesity
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Specificity
Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.
Applications Notes
ELISA: (direct and indirect: 1:2,000-1:5,000) . Immunohistochemistry: (paraffin sections, 10ug/ml) . Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.
Symbol
GRN
NCBI Official Name
Granulin
NCBI Organism
Homo sapiens
Other Product Names
Proepithelin; PEPI; PC Cell-derived Growth Factor
Tested Applications
ELISA, IHC, WB
Protein ID
NP_002078.1
Physical Properties
Liquid

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