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PLA2G1B Recombinant Protein

CAT: 0223-92-417Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-92-417Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phospholipase A2 (PLA2G1B) is a secreted protein which belongs to the phospholipase A2 family. It catalyzes the release of fatty acids from glycero-3-phosphocholines. It catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Sequences of pancreatic PLA2G1B enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Mice lacking in PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. Oral supplementation of a diabetogenic diet with the PLA2G1B inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
CAS Number
9000-83-3
NCBI Gene ID
5319
Swiss Prot
P04054
Accession Number
P04054
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Obesity, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,10% Glycerol, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
15.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Phospholipase A2 group IB
NCBI Organism
Homo sapiens
Other Product Names
PLA2G1B/Phospholipase A2/Group IB phospholipase A2/PLA2/PLA2A/PPLA2, PLA2, PLA2A
Species
Human
Physical Properties
Liquid

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