PARP-3 [ARTD3] high purity Recombinant Protein

• Background:

  PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

• NCBI Gene ID:

  10039

• Swiss Prot:

  O00626

• Accession Number:

  Q9Y6F1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  Sf21 cells

• Field of Research:

  Apoptosis, Cell Cycle

• Concentration:

  Lot dependent (0.2-1mg/ml)

• Purity:

  >98% (SDS-PAGE)

• Buffer:

  In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -80˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Poly (ADP-ribose) polymerase family, member 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Poly (ADP-ribose) Polymerase 3, ADP-ribosyltransferase Diphtheria Toxin-like 3, NAD (+) ADP-ribosyltransferase 3

• Species:

  Human

• Protein ID:

  158634478

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3