PARP-1-IN-3

PARP-1-IN-3

• CAS Number: 2976342-33-1
• UNSPSC Description: PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer[1].
• Target Antigen: Apoptosis; Caspase; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp-1-in-3.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: NC(C1=CC=CC=C1OCC2=CC=CC(NC(C3=CC=C(C=C3)Br)=O)=C2)=O
• Molecular Weight: 425.28
• References & Citations: [1]Lu G, et, al. Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1. Eur J Med Chem. 2023 May 5;251:115243.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported