PARP-1 [ARTD1] high purity Recombinant Protein

• Background:

  PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

• NCBI Gene ID:

  57097

• Swiss Prot:

  P13501

• Accession Number:

  P09874

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  Sf21 cells

• Field of Research:

  Cancer, Innate Immunity, Obesity

• Concentration:

  Lot dependent (0.2-0.5mg/ml)

• Purity:

  >98% (SDS-PAGE)

• Buffer:

  In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -80˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Poly (ADP-ribose) polymerase family, member 11

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Poly (ADP-ribose) Polymerase 1, ADP-ribosyltransferase Diphtheria Toxin-like 1, NAD (+) ADP-ribosyltransferase 1

• Species:

  Human

• Protein ID:

  156523968

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3