APRIL H98 multimeric Recombinant Protein

• Background:

  APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

• NCBI Gene ID:

  69583

• Swiss Prot:

  Q8WWA0

• Accession Number:

  Q9D777

• Tag:

  DDDDK Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Concentration:

  0.1mg/ml after reconstitution.

• Buffer:

  Contains PBS + 0.5% Trehalose. Reconstitute with 100 μ l sterile water.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 13

• NCBI Organism:

  Mus musculus

• Other Product Names:

  ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:

• Species:

  Human, Mouse

• Protein ID:

  21363035

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3