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CD40L [CD154] Recombinant Protein

CAT: 0223-90-395Size: 50 µgDry Ice: NoHazardous: No
CAT#:0223-90-395Size:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein that belongs to the TNF superfamily. As with other TNF superfamily members, CD40L will exist as a trimer, both as a membrane bound and soluble form. Multiple mutations and alternate splice forms of CD40L exist, often associated with pathology and leading to truncated or nontrimerizable forms of CD40L. CD40L binds to both CD40 and to integrin alphaIIbbeta3 (CD41) . In the cell membrane, it also associates with a unique splice variant of CD28 (CD28i) that may facilitate CD40L signal transduction. CD40L is expressed by monocytes, NK cells, mast cells, basophils, smooth muscle cells, endothelial cells, dendritic cells, activated and resting B cells, plus activated platelets and CD4+ T cells. CD40L ligation of CD40 on dendritic cells (DC) initiates DC maturation and differentiation. CD40L signaling into naive B cells promotes germinal center formation and isotope switching. CD40-CD40L seems to bridge innate and adaptive immune signals.
CAS Number
9000-83-3
NCBI Gene ID
959
Swiss Prot
Q9Y6W8
Accession Number
NP_000065
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Apoptosis, Immunology, Signal Transduction
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
CD40 ligand
NCBI Organism
Homo sapiens
Other Product Names
CD154, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5, Gp39
Species
Human
Protein ID
4557433
Physical Properties
Lyophilized

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