IL-4 R alpha / CD124 Recombinant Protein

• Background:

  IL-4 R alpha is also known as IL4R, CD124, IL-4RA.This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Interleukin-4 receptor has been shown to interact with SHC1.

• NCBI Gene ID:

  3566

• Swiss Prot:

  P24394

• Accession Number:

  NP_000409.1

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Immunology

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  50.4 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Interleukin 4 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tundup S., 2012, Ann. N. Y. Acad. Sci., 1253: E1–E13.

• Background Reference 02:

  Ikizawa K, Yanagihara Y., 2000, Biochem. Biophys. Res. Commun., 268 (1) : 54–9.

• Background Reference 03:

  Kashiwada M., 2001, J. Immunol., 167 (11) : 6382–7.

• Other Product Names:

  IL4R, CD124, IL4RA

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3