IL-4 R alpha Recombinant Protein

• Background:

  IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Ralpha (CD124) subunit and the 70 kDa common cytokine γc chain (CD132) . Interleukin 4 Receptor (IL4R) also known as CD124, IL4Ralpha and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.

• NCBI Gene ID:

  16190

• Swiss Prot:

  P16382

• Accession Number:

  NP_001008700

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  26.3 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Interleukin-4 receptor subunit alpha precursor

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 : 54–9.

• Background Reference 02:

  Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11) : 6382–7.

• Background Reference 03:

  Hage T., et al., 1999, Cell 97 (2) : 271–81.

• Background Reference 04:

  Gessner, A. et al., 2000, Immunobiology. 201 (3-4) : 285-307.

• Other Product Names:

  IL4R, CD124, IL4RA

• Tested Applications:

  WB

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3