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IL-4 receptor alpha (CD124), soluble

CAT: 0209-S01-029-L250Size: 250 µgDry Ice: NoHazardous: No
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Description
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain. The type I receptor contains, in addition to the gamma chain, an IL-4R alpha subunit, whereas the type II receptor contains the IL-13R alpha. The secreted extracellular domain of IL-4R alpha, called sIL-4R alpha, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant Human sIL-4 Receptor alpha is a 23.9 kDa glycoprotein corresponding to 209 amino acid residues of the extracellular domain of IL-4R alpha. As a result of glycosylation, Recombinant Human sIL-4 Receptor alpha migrates with an apparent molecular mass of approximately 50-65 kDa by SDS-PAGE gel, under reducing conditions.
Synonyms
Soluble Interleukin-4Rα, soluble IL-4 Receptor alpha, CD124
NCBI Gene ID
3566
UniProt
P24394
Accession Number
NP_000409.1
Accession Number mRNA
NM_000418
Chromosomal Location
16p12.1-p11.2
Reactivity
Human
Cross Reactivity
Human
Sequence
GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is ≤ 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of ≥ 2 x 105 units/mg.
Length
209
Form
Lyophilized
Molecular Weight
23.9 kDa
Host or Source
CHO cells

UniProtKB · P24394

Interleukin-4 receptor subunit alpha

IL4RA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24394
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL4R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA
EC number
—
Processing
Precursor
Secondary accessions
B4E076, B9EKU8, H3BSY5, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Immunity

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

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Alternative Products

CatalogName
MBS692482-01Human IL-4 receptor alpha (CD124), soluble
592484Interleukin 4 Receptor alpha (IL-4R alpha, CD124)
abx121566-01Interleukin-4 Receptor Subunit Alpha (CD124) Antibody
360551-01IL4R (Interleukin-4 Receptor Subunit alpha, IL-4 Receptor Subunit alpha, IL-, R Subunit alpha, IL-4R-alpha, IL-4RA, CD124, Soluble Interleukin-4 Receptor Subunit alpha, Soluble IL-4 Receptor Subunit alpha, Soluble IL-4R-alpha) discontinued
592484-APCInterleukin 4 Receptor alpha (IL-4R alpha, CD124) (APC)
592484-PEInterleukin 4 Receptor alpha (IL-4R alpha, CD124) (PE)
MBS6382817-01IL4R (Interleukin-4 Receptor Subunit alpha, IL-4 Receptor Subunit alpha, IL-4R Subunit alpha, IL-4R-alpha, IL-4RA, CD124, IL4RA, 582J2.1, Soluble Interleukin-4 Receptor Subunit alpha, Soluble IL-4 Receptor Subunit alpha, Soluble IL-4R-alpha, sIL4Ralpha/pr
167665IL-4 R alpha (Interleukin 4 Receptor alpha, CD124) (PerCP) discontinued
MBS691606-01Human IL-2 receptor alpha, soluble

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