CD124 Recombinant Protein

CAT: 0223-96-472Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-96-472Size:0.05 mg
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Background
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124) subunit and the 70 kDa common cytokine γc chain (CD132) . Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.
CAS Number
9000-83-3
NCBI Gene ID
3566
Swiss Prot
P24394
Accession Number
NP_000409.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
24.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Interleukin 4 receptor
NCBI Organism
Homo sapiens
Background Reference 01
Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 : 54–9.
Background Reference 02
Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11) : 6382–7.
Background Reference 03
Hage T., et al., 1999, Cell 97 (2) : 271–81.
Background Reference 04
Gessner, A. et al., 2000, Immunobiology. 201 (3-4) : 285-307.
Other Product Names
IL4R, CD124, IL4RA
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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