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STUB1 Recombinant Protein

CAT: 0223-91-098Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-098Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
CAS Number
9000-83-3
NCBI Gene ID
10273
Swiss Prot
Q9UNE7
Accession Number
Q9UNE7
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
34.86 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
STIP1 homology and U-box containing protein 1
NCBI Organism
Homo sapiens
Other Product Names
E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP
Species
Human
Physical Properties
Liquid

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