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STUB1 Antibody

CAT: 0223-62-277Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-277Size:400 µL
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Background
CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase (s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.
NCBI Gene ID
10273
Swiss Prot
Q9UNE7
Accession Number
Q9UNE7
Host
Rabbit
Reactivity
Human
Immunogen
This STUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human STUB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
35 kDa
Fragment
Rabbit Ig
Symbol
STUB1
NCBI Official Name
E3 ubiquitin-protein ligase CHIP
NCBI Organism
Homo sapiens
Background Reference 01
Peng, H.M., et al. J. Biol. Chem. 279 (51), 52970-52977 (2004)
Background Reference 02
Alberti, S., et al. Mol. Biol. Cell 15 (9), 4003-4010 (2004)
Background Reference 03
Beausoleil, S.A., et al. PNAS 101 (33), 12130-12135 (2004)
Background Reference 04
He, B., et al. J. Biol. Chem. 279 (29), 30643-30653 (2004)
Other Product Names
HGNC:11427
Tested Applications
WB, IHC-P
Protein ID
78099173
Physical Properties
Liquid

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