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ADAM17 Recombinant Protein

CAT: 0223-96-968Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-96-968Size:0.05 mg
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Background
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
CAS Number
9000-83-3
NCBI Gene ID
11491
Swiss Prot
Q9Z0F8
Accession Number
Q9Z0F8
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
50 mM MES, 150 mM NaCl, pH6.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
63.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Disintegrin and metalloproteinase domain-containing protein 17
NCBI Organism
Mus musculus
Background Reference 01
Black R., et al., 1997, Nature 385 (6618) : 729–33
Background Reference 02
Moss M., et al., 1997, Nature 385 (6618) : 733–6
Background Reference 03
Schroeter E., et al., 1998, Nature 393 (6683) : 382–6.
Other Product Names
ADAM17, TACE, CD156b
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized

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