CD3 delta Recombinant Protein

• Background:

  CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK) . Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

• NCBI Gene ID:

  102133701

• Swiss Prot:

  Q95LI8

• Accession Number:

  Q95LI8

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Immunology, Neuroscience, Signal Transduction, Stem Cell, Other

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  14.3 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  CD3d molecule, delta (CD3-TCR complex)

• NCBI Organism:

  Macaca fascicularis

• Background Reference 01:

  Gil J, et al., 2011, J Clin Invest, 121 (10) :3872-6.

• Background Reference 02:

  Lu X, et al.,2011, Hematology, 16 (3) :185-9.

• Background Reference 03:

  Kim ST, et al., 2010, J Immunol, 185 (5) :2951-9.

• Other Product Names:

  CD3D, CD3-DELTA, T3D

• Tested Applications:

  WB

• Species:

  Cynomolgus monkey

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3