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CD3 Epsilon Recombinant Protein

CAT: 0223-96-171Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-171Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
CAS Number
9000-83-3
NCBI Gene ID
916
Swiss Prot
P07766
Accession Number
NP_000724.1
Tag
C-Fc, His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction, Stem Cell, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
39.2 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD3e molecule, epsilon (CD3-TCR complex)
NCBI Organism
Homo sapiens
Background Reference 01
Gold DP, et al., 1986, Nature 321 (6068) : 431–4.
Background Reference 02
Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21) : 8156–60.
Background Reference 03
De Saint Basile G, et al., 2004, J. Clin. Invest. 114 (10) : 1512–7.
Background Reference 04
Wong S, et al., 1991, Clin. Exp. Immunol. 83 (1) : 69–73.
Other Product Names
FLJ18683, T3E, TCRE, CD3E, CD3-epsilon
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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