CD155 / PVR Recombinant Protein

• Background:

  CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that is encoded by the PVR gene. CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.

• NCBI Gene ID:

  52118

• Accession Number:

  NP_081790.1

• Tag:

  Mouse IgG Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Infectious Disease, Neuroscience

• Purity:

  >95% as determined by reduced SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  61.8 kDa

• Applications Notes:

  This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 61.8 kDa. The protein migrates as 35 kDa and 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Poliovirus receptor

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Zhang P., et al., 2008, Proc. Natl. Acad. Sci., 105 (47) : 18284-18289.

• Background Reference 02:

  Maier MK., et al., 2007, European Journal of Immunology, 37 (8) : 2214-2225.

• Background Reference 03:

  He Y., et al., 2000, Proc. Natl. Acad. Sci., 97 (1) : 79-84.

• Other Product Names:

  PVR, FLJ25946, PVS, CD155, TAGE4, HVED, NECL5

• Tested Applications:

  ELISA, WB

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3